Hi JJ I haven't been on here for a long time, so don't know where you are at at present. My hubby was diagnosed with Stage iv Advanced RCC in February 2013. He has been taking Votrient 800mg since May 2013 (nearly a year), he does get some side effects and at times they can be quite unpleasant, but overall he is doing good. He still works full time and we took a leaf out of Johns book and have been doing quite a bit of travelling, which is all manageable. So far the Votrient is working with some tumours reducing substantially and others disappearing all together. My only advice is to research and ask lots of questions, in our experience unless you ask the doctors do not freely give out information. Let us know what treatment plan you ended up going with. Take Care Denise ... View more