Hi @Martin61  I'm sorry to hear about your wife's diagnosis.   In my experience, the patient will work closely with the treatment team and they can provide feed back on how you are feeling. The neuropathy in my case didn't come on all of a sudden, but increased slowly over time. The important part here is a good dialog and communication with your treatment team.   I am quite some time post treatment (about 6 years), so I can offer you a long term view to this. I had bowel cancer and received 12 rounds of folfox. Initially it started as just a tingling in my fingers and a loss of feeling in my hands and feet.  Later in the treatment it would result in pins and needles in the face and sometimes difficulty breathing. The doctors and nurses will monitor you closely. As I approached the end of my treatment the peripheral neuropathy got worse.  The doctors decided to stop the Oxaliplatin (the drug that was causing the neuropathy). I was left with some residual loss of feeling in my hands and feet, that improved over time.   -s ... View more