Hi Ladies, I'm 38 and I've been on hrt for 15 years (not cancer related). One of the things I can really recommend to deal with progesterone side effects is Evening Primrose Oil. You can buy it from Supermarkets (probably good to check with your doctor first, to make sure it won't interact badly with other medications). I take 2 capsules in the morning and evening when I'm taking the progresterone component of my hrt, and find it helps with my PMS type symptoms. Hope everything goes well for you all. love Emily